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Macrolides isolated from the cyanobacterium Nostoc that have potent antimitotic activity. They bind strongly to β-tubulin (sharing a binding site with dolastatin 10, hemiasterlin, and phomopsin A), interfering with microtubule dynamics and deactivate the Bcl-2 protein causing rapid apoptosis. May have potential in chemotherapy.

Subjects: Medicine and Health.

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