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A transcriptional repressor (CCCTC-binding factor, 727 aa) that binds to promoters of c-myc, polo-like kinase, and PIM1 genes but is a transcriptional activator of the gene for amyloid precursor protein. May act as a tumour suppressor and mutations in the gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumours.

Subjects: Medicine and Health — Genetics and Genomics.

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