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A domain (C-terminal domain) unique to RNA polymerase II that is an important binding site for the various protein factors involved in RNA-processing. Phosphorylated CTD-interacting factor 1 (704 aa) may play a role in transcription elongation or in coupling transcription to pre-mRNA processing. The CTDP1 gene encodes RNA polymerase II subunit A. CTD phosphatase (C-terminal domain phosphatase, EC, 961 aa) dephosphorylates serines in the heptad repeats YSPTSPS found in the CTD which promotes the activity of RNA polymerase II. Mutations in CTDP1 are a cause of congenital cataracts, facial dysmorphism, and neuropathy syndrome.

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