'CTLA-4' can also refer to...


Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4

Targeted engagement of CTLA‐4 prevents autoimmune thyroiditis

Therapeutic use of anti-CTLA-4 antibodies

The CTLA-4 gene is expressed in placental fibroblasts

CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model

CD25+CD4+ regulatory T cells exert in vitro suppressive activity independent of CTLA-4

Serum soluble CTLA-4 levels are increased in diffuse cutaneous systemic sclerosis

An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies

Variants of the CTLA4 gene that segregate with autoimmune diseases are not associated with endometriosis

The CTLA-4 +49GG genotype is associated with susceptibility for nephrotic kidney diseases

Anti-CTLA-4 antibody-induced Guillain–Barré syndrome in a melanoma patient

CTLA-4 is required for the induction of high dose oral tolerance.

Tyrosine‐mediated inhibitory signals contribute to CTLA‐4 function in vivo

Insulin-Dependent Diabetes Mellitus (IDDM) Is Associated with CTLA4 Polymorphisms in Multiple Ethnic Groups

Intraarticular gene delivery of CTLA4–FasL suppresses experimental arthritis

Stable Skin-specific Overexpression of Human CTLA4-Ig in Transgenic Mice through Seven Generations

Feline Immunodeficiency Virus Infection Is Characterized by B7+CTLA4+ T Cell Apoptosis

Anti-GBM disease following CTLA4 blockade in a patient with metastatic melanoma


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A transmembrane protein (CD152, 223 aa) of the immunoglobulin superfamily, found on activated T cells and similar to the T-cell costimulatory CD28. Both CTLA-4 and CD28 bind to B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells but CTLA4 transmits an inhibitory signal to T cells, whereas CD28 is stimulatory. The CTLA-4 cytoplasmic domain interacts with SH2 domain of Shp2 (protein tyrosine phosphatase) and possibly with PI3-kinase. Genetic variation in CTLA4 influences susceptibility to systemic lupus erythematosus, diabetes type 1, coeliac disease type 3, hepatitis B virus infection, and possibly susceptibility to Graves' disease.

Subjects: Medicine and Health.

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