C-type lectin

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One of the two classes of lectin produced by animal cells. C-type lectins require disulphide-linked cysteines and calcium ions for binding to carbohydrate. The carbohydrate recognition domain (CRD) that confers specificity is ~130 aa with 18 invariant residues including cysteines in a highly conserved pattern. All identified C-type lectins are extracellular proteins although some are integral membrane-bound proteins, such as the asialoglycoprotein receptor. Compare S-type lectins.

Subjects: Medicine and Health.

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