cyclin-dependent kinase inhibitors

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'cyclin-dependent kinase inhibitors' can also refer to...

cyclin-dependent kinase inhibitors

Cell cycle regulatory molecules (cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors) and the cardiovascular system; potential targets for therapy?

Arresting developments in the cardiac myocyte cell cycle: Role of cyclin-dependent kinase inhibitors

Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy

Cardiac differentiation in Xenopus requires the cyclin-dependent kinase inhibitor, p27Xic1

Opposite Regulation of the Expression of Cyclin-Dependent Kinase Inhibitors during Contact Inhibition

Cyclin-dependent kinase inhibitor expression in human heart failure. A comparison with fetal development

In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas†

Analysis of the cyclin-dependent kinase inhibitors p18 and p19 in mantle-cell lymphoma and chronic lymphocytic leukemia

Mechanisms underlying maintenance of smooth muscle cell quiescence in rat aorta: role of the cyclin dependent kinases and their inhibitors

Adenoviral Expression of the Cyclin-Dependent Kinase Inhibitor p27Kip1: a Strategy for Breast Cancer Gene Therapy

Searching for Selective Cyclin-Dependent Kinase Inhibitors to Target the Retinoblastoma/p16 Cancer Gene Pathway

Selective In Vivo and In Vitro Effects of a Small Molecule Inhibitor of Cyclin-Dependent Kinase 4

p16/Cyclin-Dependent Kinase Inhibitor 2A Deficiency in Human Melanocyte Senescence, Apoptosis, and Immortalization: Possible Implications for Melanoma Progression

Dual Suppression of the Cyclin-Dependent Kinase Inhibitors CDKN2C and CDKN1A in Human Melanoma

Amelioration of nephropathy in mice expressing HIV-1 genes by the cyclin-dependent kinase inhibitor flavopiridol

The Cyclin-Dependent Kinase Inhibitor p57Kip2 Regulates Cell Cycle Exit, Differentiation, and Migration of Embryonic Cerebral Cortical Precursors

Induction of cyclin-dependent kinase inhibitors and G1 prolongation by the chemopreventive agent N-acetylcysteine

The cyclin-dependent kinase inhibitor, p21WAF1, promotes angiogenesis by repressing gene transcription of thioredoxin-binding protein 2 in cancer cells


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Two classes of CKIs are known in mammals, the cip1/kip1 family (including p27KIP1, p57KIP2, and Waf-1) that inhibit G1/S cyclin-dependent kinases (cdks), and the INK4 class that bind and inhibit only cdk4 and cdk6. The p21CIP1 inhibitor is transcriptionally regulated by p53 tumour suppressor and is important for the G1 DNA-damage checkpoint.

Subjects: Medicine and Health.

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