An antibiotic synthesized by Streptomyces griseus. The drug inhibits translation on 80S ribosomes. Therefore, it suppresses cytosolic protein synthesis without affecting the synthesis of proteins in mitochondria or chloroplasts. Protein synthesis in these organelles can be specifically inhibited by chloramphenicol, erythromycin, or tetracycline. See ribosome, ribosomes of organelles.
Subjects: Genetics and Genomics.