Overview

cyclo-oxygenase


'cyclo-oxygenase' can also refer to...

cyclo-oxygenase

cyclo-oxygenase

cyclo-oxygenase

Cyclo-oxygenase-2 inhibitors

Cyclo‐oxygenase‐2 and renal function

Translational medicine: targetting cyclo‐oxygenase isozymes to prevent cancer

Pathogen‐induced expression of cyclo‐oxygenase homologue in hot pepper (Capsicum annuum cv. Pukang)

Expression of cyclo-oxygenase types-1 and -2 in human myometrium throughout pregnancy

Expression of cyclo-oxygenase in human endometrium during the implantation period

Cyclo-Oxygenase-2 Knockout Genotype in Mice Is Associated With Blunted Angiotensin II-Induced Oxidative Stress and Hypertension

The influence of cyclo-oxygenase specificity of non-steroidal anti-inflammatory drugs on bleeding complications in concomitant coumarine users

Evidence that a prostanoid produced by cyclo-oxygenase-2 enhances contractile responses of the porcine isolated coronary artery following exposure to lipopolysaccharide

NF-κB and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line (WISH)

Corticotrophin-releasing hormone and platelet-activating factor induce transcription of the type-2 cyclo-oxygenase gene in human fetal membranes

Urinary trypsin inhibitor down-regulates hyaluronic acid fragment-induced prostanoid release in cultured human amnion cells by inhibiting cyclo-oxygenase-2 expression

Mechanism of basic calcium phosphate crystal-stimulated cyclo-oxygenase-1 up-regulation in osteoarthritic synovial fibroblasts

Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor

Non‐selective and cyclo‐oxygenase‐2‐specific non‐steroidal anti‐inflammatory drugs impair the hyperaemic response of skin to brief axillary artery occlusion

Human labour is associated with nuclear factor-κB activity which mediates cyclo-oxygenase-2 expression and is involved with the ‘functional progesterone withdrawal’

 

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(COX)

An enzyme complex present in most tissues that produces various prostaglandins and thromboxanes from arachidonic acid and that is inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin. Three isoforms are known, COX-1, COX-2, and COX-3. COX-1 (prostaglandin G/H synthase 1, EC 1.14.99.1, 599 aa) and COX-2 (604 aa) are both inhibited by aspirin. Many selective COX-2 inhibitors such as celecoxib have the analgesic and anti-inflammatory activity but do not affect the gastric mucosa in the same way as the nonselective NSAIDs; they have other side effects, however, and some have been withdrawn. In humans, a putative COX-3 mRNA is expressed in cerebral cortex and heart; paracetamol (acetaminophen) may inhibit this COX variant.

Subjects: Medicine and Health.


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