Overview

cyclopamine


Show Summary Details

Quick Reference

An alkaloid, produced by the skunk cabbage Veratrum californicum, that is a potent teratogen and causes major developmental defects (e.g. cyclopia) by blocking the hedgehog signalling pathway. Cyclopamine will block the oncogenic effects of mutations of patched (see Gorlin's syndrome).

Subjects: Medicine and Health.


Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.