A family of proteins characterized by 16 conserved cysteine residues. Cysteine-rich secretory protein-1 (CRISP-1, 249 aa) is found in the male reproductive tract and may have a role in sperm–egg fusion; CRISP-2 (243 aa) is found in testis and epididymis. CRISP-3 (245 aa) is found in the salivary gland, pancreas, and prostate, also in the specific granules of neutrophils. A number of other members of the family are known, some with LCCL domains (e.g. CRISP-10, trypsin inhibitor Hl, 500 aa). See helothermine; resistin.
Subjects: Medicine and Health.