Proteins (DDBs) that are involved in the initial recognition of ultraviolet-damaged DNA and mediate recruitment of nucleotide excision repair factor. In vivo, UV-DDB plays an important role in the p53-dependent response of mammalian cells to DNA damage. Mutations in the DDB2 gene inactivate UV-DDB in individuals from complementation group E of xeroderma pigmentosum. The damaged DNA-binding protein complex consists of a heterodimer of p127 (DDB1) and p48 (DDB2) subunits.
Subjects: Medicine and Health.