damaged DNA-binding proteins

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damaged DNA-binding proteins

Drosophila Damaged DNA Binding Protein 1 Contributes to Genome Stability in Somatic Cells

Binding activity of replication protein A to UV-damaged single-stranded DNA

Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO

p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding

FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response

PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks

Characterization of the binding of distamycin A to damaged DNA: A comparison with the DNA recognition of the human DDB protein

Recovery of DDB1a (DAMAGED DNA BINDING PROTEIN1a) in a Screen to Identify Novel RUB-Modified Proteins in Arabidopsis thaliana

Overexpression of UV-DAMAGED DNA BINDING PROTEIN 1 links plant development and phytonutrient accumulation in high pigment-1 tomato

UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2

Polymorphisms in DNA damage binding protein 2 (DDB2) and susceptibility of primary lung cancer in the Chinese: a case–control study

The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis

Drosophila damage‐specific DNA‐binding protein 1 (D‐DDB1) is controlled by the DRE/DREF system

Purification of a Novel UV-Damaged-DNA Binding Protein Highly Specific for (6–4) Photoproduct

Photocrosslinking locates a binding site for the large subunit of human replication protein A to the damaged strand of cisplatin-modified DNA

A novel UV-damaged DNA binding protein emerges during the chromatin-eliminating cleavage period in Ascaris suum

cDNA Cloning, Tissue Expression, and Chromosomal Assignment of a Mouse Gene, Encoding a 127 kDa UV-damaged DNA Binding Protein Which is Defective in XPE Cells

PSI-BLAST searches using hidden Markov models of structural repeats: prediction of an unusual sliding DNA clamp and of β-propellers in UV-damaged DNA-binding protein


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Proteins (DDBs) that are involved in the initial recognition of ultraviolet-damaged DNA and mediate recruitment of nucleotide excision repair factor. In vivo, UV-DDB plays an important role in the p53-dependent response of mammalian cells to DNA damage. Mutations in the DDB2 gene inactivate UV-DDB in individuals from complementation group E of xeroderma pigmentosum. The damaged DNA-binding protein complex consists of a heterodimer of p127 (DDB1) and p48 (DDB2) subunits.

Subjects: Medicine and Health.

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