Overview

DAP-12


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A signalling adaptor (DNAX-activating protein-12, 113 aa), expressed by NK cells, B cells, and T cells, that resembles the γ-chain of FcεRI and the ζ-chain of the T-cell receptor. It interacts through an immunoreceptor tyrosine-based activation motif (ITAM) with zap-70 and syk and thus activates NK cells, although it has been implicated in inhibitory signalling in mouse macrophages and dendritic cells. Defects cause Nasu–Hakola disease. See TREM-2.

Subjects: Medicine and Health.


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