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daptomycin


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A cyclic lipopeptide antibiotic that is active against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus, glycopeptide-intermediate and -resistant S. aureus, and vancomycin-resistant Enterococcus faecalis and E. faecium (VRE). Acts by inhibiting lipoteichoic acid synthesis as a consequence of membrane binding in the presence of calcium.

Subjects: Clinical Pharmacology and Therapeutics.


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