An oncogene (cell line-derived transforming sequence, MCF2) originally identified by transfection of NIH-3T3 cells with DNA from human diffuse B-cell lymphoma. The product, Dbl, is a guanine nucleotide exchange factor (GEF) for rho family members and has a Dbl-homology (DH) domain. The DH domain is a cytoskeletal modulation-type domain (~150 aa) arranged as an extended bundle of alpha-helices that is found in Dbl, Vav, and a family of other Dbl-family proteins (Lfc, Lsc, Ect2, Dbs, Brx). DH domains are invariably located immediately N-terminal to a PH domain that is required for normal function. The Dbl family of related proteins with similar functions and containing a DH domain includes Dbl itself, Dbs, Brx, Lfc, Lsc, Ect2, DRhoGEF2, and Vav.
http://pawsonlab.mshri.on.ca/index.php?option=com_content&task=view&id=154&Itemid=64 For details of the dbl domain.
Subjects: Medicine and Health.