death-associated protein

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A basic, proline-rich protein (DAP-1, 102 aa) thought to be a positive mediator of programmed cell death induced by interferon-γ. Death-associated protein-3 (DAP3, 398 aa) is a component of the 28S mitochondrial ribosome subunit. Death-associated protein 6 (Fas-binding protein, Daxx, 760 aa) is an interferon-induced protein that binds to the Fas death domain and enhances Fas-mediated apoptosis and is a component of nuclear promyelocytic leukaemia protein (PML) oncogenic domains (PODS). Acts downstream of apoptosis signal-regulating kinase (ASK1). Death-associated protein kinase-1 (DAP-kinase, EC, 1430 aa) is one of a proapoptotic family of multidomain calcium/calmodulin (CaM)-dependent Ser/Thr protein kinases that are phosphorylated upon activation of the ras-extracellular signal-regulated kinase (ERK) pathway. Loss of DAP kinase expression in sporadic pituitary tumours is associated with invasive behaviour. DAP-Kinase-3 is identical to zip kinase. DAP-related apoptotic kinase-2 (DRAK2, 372 aa) is thought to be a positive regulator of apoptosis in thymocyte selection and lymphoid maturation.

Subjects: Medicine and Health.

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