DEAD box

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DEAD box


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The DEAD box RNA helicase family in Arabidopsis thaliana

Functional Characterization of DEAD-Box RNA Helicases in Arabidopsis thaliana under Abiotic Stress Conditions

The DEAD-box helicase DDX3 supports the assembly of functional 80S ribosomes

Ddx42p—a human DEAD box protein with RNA chaperone activities

p72: A Human Nuclear DEAD Box Protein Highly Related to p68

Genetic Interactions of Conserved Regions in the DEAD-Box Protein Prp28p

Characterization of a DEAD box ATPase/RNA helicase protein of Arabidopsis thaliana

Synergistic effects of ATP and RNA binding to human DEAD-box protein DDX1

Molecular cloning and characterization of a salinity stress-induced gene encoding DEAD-box helicase from the halophyte Apocynum venetum

OsBIRH1, a DEAD-box RNA helicase with functions in modulating defence responses against pathogen infection and oxidative stress

A DEAD-Box Protein, AtRH36, is Essential for Female Gametophyte Development and is Involved in rRNA Biogenesis in Arabidopsis

Crystal structure, mutational analysis and RNA-dependent ATPase activity of the yeast DEAD-box pre-mRNA splicing factor Prp28

DEAD-box RNA helicase domains exhibit a continuum between complete functional independence and high thermodynamic coupling in nucleotide and RNA duplex recognition

DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis

eIF4G stimulates the activity of the DEAD box protein eIF4A by a conformational guidance mechanism

Nucleolar proteins Bfr2 and Enp2 interact with DEAD-box RNA helicase Dbp4 in two different complexes


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A four amino acid consensus, -D-E-A-D- (Asp-Glu-Ala-Asp), that resembles an ATP binding site of the Walker B type. DEAD-box helicases are a family of ATP-dependent DNA or RNA helicases belonging to the second superfamily of helicases (SFII), the DExD/H-box RNA helicases (see DEAH-box proteins). They are important in RNA metabolism in both eukaryotes and prokaryotes and may have important functions in mediating microbial pathogenesis. Humans have 36 putative DEAD-box helicases including p68, a nuclear protein involved in cell growth. DEAD proteins have multiple DEAD motifs, and several hundreds of these proteins can be identified in databases. Not all have helicase activity and it may be that their role is to alter the conformation of RNA, thus regulating its binding interaction with proteins.

Subjects: Medicine and Health — Chemistry.

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