'decapping' can also refer to...


Control of mRNA decapping by autoinhibition

Premature termination codons enhance mRNA decapping in human cells

Diffuse Decapping Enzyme DCP2 Accumulates in DCP1 Foci Under Heat Stress in Arabidopsis thaliana

Diauxic shift-dependent relocalization of decapping activators Dhh1 and Pat1 to polysomal complexes

Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2)

miRISC recruits decapping factors to miRNA targets to enhance their degradation

Bisphosphonate mRNA cap analog attached to Sepharose for affinity chromatography of decapping enzymes

Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects

Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment

In plants, decapping prevents RDR6-dependent production of small interfering RNAs from endogenous mRNAs

DNA3′pp5′G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition

Insights into the molecular determinants involved in cap recognition by the vaccinia virus D10 decapping enzyme

Identification of mRNA decapping activities and an ARE‐regulated 3′ to 5′ exonuclease activity in trypanosome extracts

Initiation‐mediated mRNA decay in yeast affects heat‐shock mRNAs, and works through decapping and 5′‐to‐3′ hydrolysis

Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme

Mutational analysis of a Dcp2-binding element reveals general enhancement of decapping by 5′-end stem-loop structures

Decapping Reaction of mRNA Requires Dcp1 in Fission Yeast: Its Characterization in Different Species from Yeast to Human

The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1


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Removal of the mRNA 5′ cap structure, a key step in mRNA turnover, is catalysed by the Dcp1–Dcp2 complex (the decapping complex). Decay is initiated by poly-A shortening, and oligoadenylated mRNAs (but not polyadenylated mRNAs) are selectively decapped allowing their further degradation by the 5′ to 3′ exonuclease XRN1. The decapping activator complex is made up of the highly conserved heptameric Lsm1p–7p complex (made up of the seven Like Sm proteins, Lsm1p–Lsm7p) and their interacting partner, Pat1p. It activates decapping by an unknown mechanism and localizes with other decapping factors to the P-bodies in the cytoplasm. See GW bodies.

Subjects: Medicine and Health.

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