Overview

decoy receptor


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In general, a receptor that competes for binding of a ligand but does not induce a response, thereby diluting the signal's effect. More specifically, decoy receptors DcR1 (259 aa) and DcR2 (386 aa) compete with death receptor 4 (DR4) or DR5 for binding to the ligand (TRAIL); decoy receptor 3 (DcR3, 300 aa) and osteoprotegerin are soluble receptors for Fas ligand and apparently act as decoy receptors. Other soluble receptors, which bind ligand but cannot transduce a signal, are being identified and this may be a widespread mechanism for damping signalling systems.

Subjects: Medicine and Health.


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