decoy receptor

Show Summary Details

Quick Reference

In general, a receptor that competes for binding of a ligand but does not induce a response, thereby diluting the signal's effect. More specifically, decoy receptors DcR1 (259 aa) and DcR2 (386 aa) compete with death receptor 4 (DR4) or DR5 for binding to the ligand (TRAIL); decoy receptor 3 (DcR3, 300 aa) and osteoprotegerin are soluble receptors for Fas ligand and apparently act as decoy receptors. Other soluble receptors, which bind ligand but cannot transduce a signal, are being identified and this may be a widespread mechanism for damping signalling systems.

Subjects: Medicine and Health.

Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.