7-dehydrocholesterol reductase

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EC; systematic name: 3β‐hydroxysteroid‐Δ7‐reductase; an enzyme of the endoplasmic reticulum that reduces 7‐dehydrocholesterol to cholesterol, using NADPH as coenzyme. The gene at 11q12‐q13 encodes a multipass transmembrane protein of 475 amino acids. Inactivating mutations are responsible for Smith—Lemli—Opitz syndrome.


Subjects: Chemistry.

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