delayed rectifier channels

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Neuronal ion channels that change their conductance for potassium ions with a brief delay following a voltage step. They control action potential repolarization, interspike membrane potential, and action potential frequency in excitable cells and are also important in stimulus–secretion coupling. A-type potassium channels can be converted into delayed rectifier-type channels by alterations in membrane lipid, and arachidonic acid and anandamide will change delayed rectifier channels into rapid voltage-dependent inactivation-type channels.

http://www.sciencemag.org/cgi/content/abstract/1094113v1 Additional detail in ‘Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids’ in Science (2004).

Subjects: Medicine and Health.

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