deleted in colorectal cancer

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The DCC gene, deleted in 70% of colorectal cancers, encodes a protein of the immunoglobulin superfamily with considerable homology to neural cell adhesion molecule-14. May be involved in regulation of cell–cell or cell–substratum interactions with a potential functional role in the control of cell growth, cell differentiation, and development of metastases. It is one of a family of receptors that includes Drosophila Frazzled which binds netrin in association with one of the UNC-5 family of receptors.

Subjects: Medicine and Health.

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