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denileukin diftitox


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An engineered protein that combines IL-2 with the enzymatic and translocation domains of diphtheria toxin (DT). In effect the B subunit of DT has been replaced with IL-2 so that cells overexpressing the IL-2 receptor are targeted, the construct is internalized, processed, translocated, and the target cell killed. It has some promise as an antineoplastic agent against lymphomas. TN Ontak.

Subjects: Medicine and Health.


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