An engineered protein that combines IL-2 with the enzymatic and translocation domains of diphtheria toxin (DT). In effect the B subunit of DT has been replaced with IL-2 so that cells overexpressing the IL-2 receptor are targeted, the construct is internalized, processed, translocated, and the target cell killed. It has some promise as an antineoplastic agent against lymphomas. TN Ontak.
Subjects: Medicine and Health.