density-dependent inhibition of growth

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The cessation of cell division that occurs once cells in culture reach a critical density (topoinhibition). The number of cells per unit area at which this occurs is higher than the density at which a monolayer is formed (confluent culture) indicating that this is not a contact-mediated phenomenon, unlike contact inhibition of locomotion. Cells that are not anchorage dependent may not exhibit density dependence.

Subjects: Medicine and Health.

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