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A large and growing family of antibacterial peptides (27–34 aa) isolated from the skin of the South American frogs of the genus Phyllomedusa. They have broad-spectrum antibacterial activity, and some have antifungal and antiprotozooal activities. Structurally they are polycationic (Lys-rich), alpha-helical, and amphipathic which may allow them to interact with membrane bilayers, causing cytolysis, although they do not lyse mammalian erythrocytes. Dermaseptin S9 acts on both Gram-positive and Gram-negative bacteria. Dermaseptin O1 from Phyllomedusa oreades is also active against Trypanosoma cruzi.

http://www.copewithcytokines.de/cope.cgi?key=dermaseptins More information in Cope with Cytokines online encyclopaedia.

Subjects: Chemistry — Medicine and Health.

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