One of the tyrosine-rich acidic extracellular matrix (ECM) proteins (TRAMPs) found in many metazoa. Dermatopontin (201 aa) was first identified in skin extracts and because it binds both to cells and to dermatan sulphate proteoglycans, was named dermatopontin by analogy with osteopontin. It is found in many tissues, interacts with other ECM components, especially decorin, and is thought to regulate ECM formation and collagen fibrillogenesis. In leiomyoma development there is frequently reduced expression of dermatopontin.
Subjects: Medicine and Health.