Reactions that inactivate toxins. These generally occur in the liver, where diverse cytochrome P450 enzymes play an important part in oxidizing toxins (or other xenobiotics) as a first step in their inactivation and removal. Oxidized compounds are then conjugated to polar compounds by transferases (e.g. glutathione S-transferase) and then pumped out, sometimes after further modification. Not all toxins can be handled in this way and a range of other methods for inactivating toxins are known.
Subjects: Medicine and Health.