Overview

deubiquitinating enzymes


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A large and heterogeneous group of cysteine proteases (q.v.) that specifically cleave off polyubiquitin chains from ubiquitin-conjugated proteins or generate ubiquitin monomers from polyubiquitin chains. These enzymes are thought to have a broad range of substrate specificities and may play a regulatory role in protein ubiquitination-related processes. See otu, ubiquitin, ubiquitin-proteasome pathway (UPP).

Subjects: Genetics and Genomics.


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