A large and heterogeneous group of cysteine proteases (q.v.) that specifically cleave off polyubiquitin chains from ubiquitin-conjugated proteins or generate ubiquitin monomers from polyubiquitin chains. These enzymes are thought to have a broad range of substrate specificities and may play a regulatory role in protein ubiquitination-related processes. See otu, ubiquitin, ubiquitin-proteasome pathway (UPP).
Subjects: Genetics and Genomics.