dihydrofolate synthase

'dihydrofolate synthase' can also refer to...

dihydrofolate synthase

Construction of a homodimeric dihydrofolate reductase-thymidylate synthase bifunctional enzyme.

Isolation of the Pneumocystis carinii dihydrofolate synthase gene and functional complementation in Saccharomyces cerevisiae

Do mutations in Plasmodium falciparum dihydropteroate synthase and dihydrofolate reductase confer resistance to sulfadoxine-pyrimethamine in Iran?

Genetic Divergence of the Dihydrofolate Reductase and Dihydropteroate Synthase Genes in Pneumocystis carinii from 7 Different Host Species

A Novel Plasmodium falciparum Expression System for Assessing Antifolate Resistance Caused by Mutant P. vivax Dihydrofolate Reductase–Thymidylate Synthase

Resistance to trimethoprim–sulfamethoxazole and modifications in genes coding for dihydrofolate reductase and dihydropteroate synthase in European Streptococcus pneumoniae isolates

Pneumocystis carinii Dihydropteroate Synthase but Not Dihydrofolate Reductase Gene Mutations Correlate with Prior Trimethoprim-Sulfamethoxazole or Dapsone Use

Mutations in Plasmodium falciparum Dihydrofolate Reductase and Dihydropteroate Synthase and Epidemiologic Patterns of Pyrimethamine-Sulfadoxine Use and Resistance

Sequence Variations in the Genes Encoding Dihydropteroate Synthase and Dihydrofolate Reductase and Clinical Response to Sulfadoxine-Pyrimethamine in Patients with Acute Uncomplicated Falciparum Malaria

Gene amplification and enzyme modification are responsible for the methotrexate-resistance of two carrot cell lines that overproduce bifunctional dihydrofolate reductase-thymidylate synthase


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EC; other name: dihydrofolate synthetase; an enzyme of the pathway for the de novo synthesis of dihydrofolate. It catalyses the formation of dihydrofolate from ATP, dihydropterate, and l‐glutamate with release of ADP and orthophosphate.


Subjects: Chemistry.

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