Inhibitors of integrins (45–84 aa) that were originally isolated from various snake (viper) venoms. Almost all have a conserved RGD motif and work only on integrins that recognize this (the β1 and β3 classes). Their biological role is probably to inhibit blood clotting by competitive inhibition of integrin binding. Examples include albolabrin, applagin, batroxostatin, bitistatin, echistatin, elegantin, flavoridin, halysin, kistrin, triflavin, and trigramin.
Subjects: Medicine and Health.