'disintegrin' can also refer to...



Evolution of Snake Venom Disintegrins by Positive Darwinian Selection

Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells

Human Metalloprotease-Disintegrin Kuzbanian Regulates Sympathoadrenal Cell Fate in Development and Neoplasia

Ussuristatin 2, a Novel KGD-Bearing Disintegrin from Agkistrodon ussuriensis Venom

A disintegrin and metalloproteinases 10 and 17 modulate the immunogenicity of glioblastoma-initiating cells

Increased Expression of a Disintegrin and Metalloprotease-9 in Hepatocellular Carcinoma: Implications for Tumor Progression and Prognosis

A Novel Metalloprotease from Gloydius halys Venom Induces Endothelial Cell Apoptosis through Its Protease and Disintegrin-Like Domains

ADAMs (A Disintegrin and Metalloproteinase) Messenger RNA Expression in Helicobacter pylori—Infected, Normal, and Neoplastic Gastric Mucosa

Comparative Biochemistry of Disintegrins Isolated from Snake Venom: Consideration of the Taxonomy and Geographical Distribution of Snakes in the Genus Echis

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for α-secretase activity in fibroblasts

A disintegrin and metalloprotease-17 and galectin-9 are important regulators of local 4-1BB activity and disease outcome in rheumatoid arthritis

A disintegrin and metalloproteinase 12 (ADAM12) localizes to invasive trophoblast, promotes cell invasion and directs column outgrowth in early placental development

Cloning and Characterization of Adinbitor, a Novel Disintegrin from the Snake Venom of Agkistrodon halys brevicaudus stejneger

Vascular Induction of a Disintegrin and Metalloprotease 17 by Angiotensin II Through Hypoxia Inducible Factor 1α

The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells

A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)‐1 null mutant mice develop renal lesions mimicking obstructive nephropathy

Purification and Characterization of a New RGD/KGD-Containing Dimeric Disintegrin, Piscivostatin, from the Venom of Agkistrodon piscivorus piscivorus: The Unique Effect of Piscivostatin on Platelet Aggregation


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Inhibitors of integrins (45–84 aa) that were originally isolated from various snake (viper) venoms. Almost all have a conserved RGD motif and work only on integrins that recognize this (the β1 and β3 classes). Their biological role is probably to inhibit blood clotting by competitive inhibition of integrin binding. Examples include albolabrin, applagin, batroxostatin, bitistatin, echistatin, elegantin, flavoridin, halysin, kistrin, triflavin, and trigramin.

Subjects: Medicine and Health.

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