DNA-agar technique

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A technique for testing the degree of homology between nucleic acid molecules from different sources by allowing fragments of radioactive nucleic acid from one source to react with nonlabeled nucleic acids from another source trapped in an agar gel. This procedure binds to the gel radioactive polynucleotide fragments that are complementary to those trapped in the agar. See Chronology, 1963, McCarty and Bolton; hybrid duplex molecule.

Subjects: Genetics and Genomics.

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