The shielding of DNA sequences bound by a protein from degradation by an endonuclease. DNAase protection is used to characterize a DNA segment that binds a specific protein. In this approach, the protein in question is bound to the DNA, DNAase added to degrade the surrounding unprotected sequences, and the remaining bound DNA isolated and analyzed. See dimethyl sulfate protection, DNAase footprinting.
Subjects: Genetics and Genomics.