A system that checks for regions where DNA has single-stranded or mismatched regions or stalled replication forks. Further progress through mitosis is then halted until the damage is corrected. If it cannot be rectified, the cell is diverted to apoptosis (q.v.). See Chronology, 1989, Hartwell and Weinert; Adriamycin, ATM kinase, RAD.
Subjects: Genetics and Genomics.