A technique for selectively binding specific segments of single-stranded DNA or RNA by base pairing to complementary sequences on ssDNA molecules that are trapped on a nitrocellulose filter (q.v.). 1. DNA-DNA hybridization is commonly used to determine the degree of sequence identity between DNAs of different species. 2. DNA-RNA hybridization is the method used to select those molecules that are complementary to a specific DNA from a heterogeneous population of RNAs. See Chronology, 1960, Doty et al.; 1963, McCarty and Bolton; 1972, Kohne et al.; in situ hybridization, reassociation kinetics.
Subjects: Psychology — Genetics and Genomics.