DNA ligase genes

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In humans three genes have been identified that encode DNA ligases. LIG1 (19q13.2–13.3) joins Okazaki fragments during DNA replication (q.v.). LIG3 (17q11.2–q12) seals chromosome breaks produced during meiotic recombination. LIG4 (13q22–q34) functions during V(D)J recombination (q.v.).

Subjects: Genetics and Genomics.

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