Mutations of E. coli that influence DNA replication. The dna A, dna B, and dna C mutations are defective in proteins that interact with replication origins. The dna E, dna X, and dna Z genes encode subunits of DNA polymerase III, and dna G encodes primase (q.v.). Mutation in dnaQ damages the proofreading (q.v.) ability of the epsilon subunit of DNA polymerase III and greatly increases the mutation rate. See DNA polymerase, mutator gene, repair synthesis, replisome.
Subjects: Genetics and Genomics.