DNA primase

'DNA primase' can also refer to...

DNA primase

DNA primases

3′-Deoxyribonucleotides Inhibit Eukaryotic DNA Primase

Properties of an unusual DNA primase from an archaeal plasmid

A novel non-radioactive primase–pyrophosphatase activity assay and its application to the discovery of inhibitors of Mycobacterium tuberculosis primase DnaG

Crystallization and Preliminary X-Ray Analysis of a DNA Primase from Hyperthermophilic Archaeon Pyrococcus horikoshii

Mechanism of sequence-specific template binding by the DNA primase of bacteriophage T7

Flexible tethering of primase and DNA Pol α in the eukaryotic primosome

Class-specific restrictions define primase interactions with DNA template and replicative helicase

Flexible tethering of primase and DNA Pol α in the eukaryotic primosome

Identification and characterization of a DNA primase from the hyperthermophilic archaeon Methanococcus jannaschii

In vitro expansion of mammalian telomere repeats by DNA polymerase α-primase

Replication Protein-A Mediates the Association of Calf Thymus DNA Polymerase α-DNA Primase Complex with Guanine-Rich DNA Sequence

Functional association of poly(ADP-ribose) polymerase with DNA polymerase α-primase complex: A link between DNA strand break detection and DNA replication

Functional interplay of DnaE polymerase, DnaG primase and DnaC helicase within a ternary complex, and primase to polymerase hand-off during lagging strand DNA replication in Bacillus subtilis

DnaC traps DnaB as an open ring and remodels the domain that binds primase

XRCC1 interacts with the p58 subunit of DNA Pol α-primase and may coordinate DNA repair and replication during S phase

The DNA primase of Sulfolobus solfataricus is activated by substrates containing a thymine-rich bubble and has a 3′-terminal nucleotidyl-transferase activity

Isothermal DNA amplification using the T4 replisome: circular nicking endonuclease-dependent amplification and primase-based whole-genome amplification


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Despite the name, these are RNA polymerases (RNA primase, EC that catalyse the synthesis of short (~10 bases) RNA primers on single-stranded DNA templates. These primers are used by DNA polymerase to initiate the synthesis of Okazaki fragments on the lagging strand. Eukaryotic DNA primase is a p60/p50 heterodimer with little homology to prokaryotic primases and forms a complex with DNA polymerase-α.

Subjects: Medicine and Health — Chemistry.

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