n. an enzyme that catalyses the cleavage of DNA. A genetically engineered form, recombinant human DNAse (dornase alfa), is used in the treatment of cystic fibrosis to reduce the viscosity of the sticky secretions in the lungs. Administered by inhalation via a jet nebulizer, it appears to hydrolyse extracellular DNA that accumulates with other neutrophil debris in the airways. Trade name: Pulmozyme.
Subjects: Medicine and Health.