Overview

dominant negative mutation


'dominant negative mutation' can also refer to...

dominant negative mutation

dominant negative mutation

Dominant Negative ATM Mutations in Breast Cancer Families

Re: Dominant Negative ATM Mutations in Breast Cancer Families

RESPONSE: Re: Dominant Negative ATM Mutations in Breast Cancer Families

Dominant Negative Mutator Mutations in the mutL Gene of Escherichia Coli

A Missense Mutation in the Desmin Rod Domain Is Associated with Autosomal Dominant Distal Myopathy, and Exerts a Dominant Negative Effect on Filament Formation

ALDH18A1 gene mutations cause dominant spastic paraplegia SPG9: loss of function effect and plausibility of a dominant negative mechanism

Reply: ALDH18A1 gene mutations cause dominant spastic paraplegia SPG9: loss of function effect and plausibility of a dominant negative mechanism

An Arabidopsis ACT2 Dominant-Negative Mutation, which Disturbs F-actin Polymerization, Reveals its Distinctive Function in Root Development

A MADS Box Gene from Lily (Lilium Longiflorum) is Sufficient to Generate Dominant Negative Mutation by Interacting with PISTILLATA (PI) in Arabidopsis thaliana

Andersen mutations of KCNJ2 suppress the native inward rectifier current I K1 in a dominant-negative fashion

Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Nav1.5 α-subunits

The hMSH2(M688R) Lynch syndrome mutation may function as a dominant negative

Defective peroxisomal proliferators activated receptor gamma activity due to dominant-negative mutation synergizes with hypertension to accelerate cardiac fibrosis in mice

A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice

Mutations in the gene for connexin 26 (GJB2) that cause hearing loss have a dominant negative effect on connexin 30

A dominant negative mutation at the ATP binding domain of AMHR2 is associated with a defective anti-Müllerian hormone signaling pathway

Adaptor protein-2 sigma subunit mutations causing familial hypocalciuric hypercalcaemia type 3 (FHH3) demonstrate genotype–phenotype correlations, codon bias and dominant-negative effects

 

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A mutation which produces a product that binds to the product of the normal allele. The heteropolymer that results damages the cell. A dominant negative mutation therefore has a more severe effect than the deletion of the same gene. Several hereditary human diseases are caused by dominant negative mutations in genes that encode collagens and keratins (both of which see).

Subjects: Genetics and Genomics.


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