DREAM complex

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A multiprotein complex that represses cell cycle-dependent (cdc) genes in quiescent cells. Subunits of the complex include the transcription factors E2F4, E2F5, MYBL1, MYBL2, Dp1, and Dp2, together with retinoblastoma-like proteins, RBL1 and RBL2, the histone-binding protein, RBBP4 (retinoblastoma-binding protein 4, chromatin assembly factor 1 subunit C, 425 aa), and LIN9, LIN37 (antolefinin), LIN52, and LIN54. The complex dissociates in S phase when the LIN proteins form a subcomplex that binds to MYBL2. Compare LINC complex.

Subjects: Medicine and Health.

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