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The nuclear RNase III (EC, 1374 aa) that initiates microRNA (miRNA) processing. Originally described in Drosophila, but the human homologue is ubiquitiously expressed in tissues. Drosha interacts with the double-stranded-RNA-binding protein DGCR8 (deleted in di George syndrome) and they are both present within the 650-kDa microprocessor complex. Drosha is also a component of a larger complex containing multiple classes of RNA-associated proteins including RNA helicases, proteins that bind double-stranded RNA, novel heterogeneous nuclear ribonucleoproteins, and the Ewing's sarcoma family of proteins.

Subjects: Medicine and Health.

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