The nuclear RNase III (EC 18.104.22.168, 1374 aa) that initiates microRNA (miRNA) processing. Originally described in Drosophila, but the human homologue is ubiquitiously expressed in tissues. Drosha interacts with the double-stranded-RNA-binding protein DGCR8 (deleted in di George syndrome) and they are both present within the 650-kDa microprocessor complex. Drosha is also a component of a larger complex containing multiple classes of RNA-associated proteins including RNA helicases, proteins that bind double-stranded RNA, novel heterogeneous nuclear ribonucleoproteins, and the Ewing's sarcoma family of proteins.
Subjects: Medicine and Health.