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Highly conserved multifunctional proteins (16 kDa) involved in the formation of membrane channels. When oriented with N- and C-termini on the cytoplasmic face they are components of gap junctions; in the opposite orientation they are subunits of vacuolar-type proton pumps (C subunit of V-type ATPases). This has, however, been controversial.

Subjects: Medicine and Health.

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