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One of the blood group antigens determined by a single gene on chromosome 1. A glycoprotein (gp-Fy; CD234; 35 to 45 kDa), named GPD, on the surface of erythrocytes and endothelium of postcapillary venules has the antigenic determinants. There are five phenotypes (Fy-a, Fy-b, Fy-o, Fy-x, and Fy-y) and five antigens. Nearly all white people are Duffy-positive, whereas most people of African descent are Duffy-negative, probably because the Fy(a–, b–) phenotype confers resistance to infection by Plasmodium vivax. The Duffy blood group antigen (Duffy antigen receptor for chemokines, DARC) is also the receptor for the chemokines interleukin-8 and melanoma growth stimulatory activity (CXCL1) and these chemokines compete for binding with the malarial parasite ligand.

http://www.ncbi.nlm.nih.gov/projects/gv/mhc/xslcgi.cgi?cmd=bgmut/home Blood Group Antigen Gene Mutation Database.

Subjects: Medicine and Health.

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