Duffy blood group gene

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The first human genetic locus to be localized on a specific autosome. The gene (symbolized FY) is at 1q21–22, and its nucleotide sequence has been determined. The gene encodes a protein that contains 338 amino acids organized into several transmembrane domains. The protein functions as a receptor for various cytokines (q.v.) and for Plasmodium vivax merozoites. Individuals homozygous for mutations that repress the transcription of Duffy gene in erythrocytes resist the invasion of these malaria parasites. Practically all West Africans are Duffy negative. The blood group was named in 1950 after the patient whose blood contained antibodies against the FY gene product. See Chronology, 1968, Donahue et al.; 1976, Miller et al.; Chaudhuri et al.; G proteins, malaria, Mendelian Inheritance in Man (MIM), Plasmodium life cycle.

Subjects: Genetics and Genomics.

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