DuBose was born into the southern gentry on 11 April 1836 on a plantation near Winnsboro, South Carolina. He attended local schools and in 1855 graduated as ranking cadet officer from the state's military academy, better known as “The Citadel.” He then obtained an MA degree from the University of Virginia in 1859 and began classes at a newly established Episcopal seminary located at Camden in his native state. When the Civil War began in April of 1861, he temporarily abandoned theological studies and joined the Confederate army. Serving first as adjutant to his former college commandant and after being exchanged as a prisoner with several wounds, he was ordained a deacon in 1863 and spent the rest of the war as a chaplain. Upon returning home to Winnsboro, DuBose worked at St. John's Episcopal Church for two years. During those same years he volunteered to help at a nearby mission called St. Stephen's Chapel. It is unclear whether DuBose functioned in the capacity of deacon or priest during those years, but by 1868 he had definitely been ordained into the priesthood when he became rector of Trinity Church in Abbeville, South Carolina.
From The Dictionary of Modern American Philosophers in Oxford Reference.