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A stable 20S multiprotein assembly (10 MDa) that is required for dynein-driven movement of cytoplasmic organelles along microtubules. There are ten distinct polypeptides including dynactin 1 (1278 aa), dynamitin, and centractins. Null mutations are lethal but heterozygotes have been reported with progressive neuropathies and mutations in the dynactin 1 gene may be a susceptibility factor for amyotrophic lateral sclerosis.

Subjects: Chemistry — Medicine and Health.

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