An autosomal dominant disorder (DSH, reticulate acropigmentation of Dohi) in which there are regions of hyper- and hypopigmentation on the face and dorsal regions of hands and feet that appear in childhood and persist into adulthood, but with no adverse effect. Can be caused by mutation in the ADAR1 gene. Dyschromatosis universalis hereditaria (DUH) occurs most commonly in Japanese people but differs in that the pigmented macules are found mostly on the trunk. There is evidence of linkage to a locus on chromosome 6.
Subjects: Medicine and Health.