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n. a collection of inherited disorders of thyroid hormone synthesis resulting in low levels of thyroxine and triiodothyronine and high levels of thyroid-stimulating hormone, with consequent goitre formation. The result may be cretinism with a goitre or milder forms of hypothyroidism with a goitre. Several different stages of the production pathway for thyroid hormones can be affected.

Subjects: Medicine and Health.

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