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dystroglycan


'dystroglycan' can also refer to...

dystroglycan

dystroglycan

Is podocyte shape controlled by the dystroglycan complex?

Glycobiology of α-dystroglycan and muscular dystrophy

Glycoproteomic characterization of recombinant mouse α-dystroglycan

Matriglycan: a novel polysaccharide that links dystroglycan to the basement membrane

Expression of sialidase and dystroglycan in human glomerular diseases

Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse

Dystroglycan glycosylation and its role in matrix binding in skeletal muscle

Processing of β-dystroglycan by matrix metalloproteinase disrupts the link between the extracellular matrix and cell membrane via the dystroglycan complex

Differential glycosylation of α-dystroglycan and proteins other than α-dystroglycan by like-glycosyltransferase

Dissociation of the dystroglycan complex in caveolin-3-deficient limb girdle muscular dystrophy

Refining genotype–phenotype correlations in muscular dystrophies with defective glycosylation of dystroglycan

Ezrin-dependent regulation of the actin cytoskeleton by β-dystroglycan

Dystroglycan Is Essential for Early Embryonic Development: Disruption of Reichert's Membrane in Dag1-Null Mice

A sarcoglycan–dystroglycan complex anchors Dp116 and utrophin in the peripheral nervous system

Xylosyl- and glucuronyltransferase functions of LARGE in α-dystroglycan modification are conserved in LARGE2

Walker-Warburg Syndrome: Genetic Heterogeneity Converging at the Abnormal Glycosylation of Alpha-Dystroglycan

Sarcolemma instability during mechanical activity in Largemyd cardiac myocytes with loss of dystroglycan extracellular matrix receptor function

 

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A component of the dystrophin-associated protein complex, dystrophin-associated glycoprotein, that is proteolytically processed to produce α-dystroglycan (624 aa) which is an extracellular laminin-binding glycoprotein that remains associated with transmembrane β-dystroglycan (242 aa) that associates with dystrophin in the cytoplasm. The actin cytoskeleton is linked, via dystrophin and dystroglycans, to the extracellular matrix. α-Dystroglycan also binds agrin and neurexin. Post-translational modification of α-dystroglycan by the LARGE acetylglucosaminyltransferase is essential for normal function and to prevent muscle degeneration. Hypoglycosylation of dystroglycan is a feature of Fukuyama muscular dystrophy and muscle–eye–brain disease.

Subjects: Medicine and Health.


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