E5, E6, E7

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Papillomavirus oncogenes. The E5 product binds and blocks the 16-kDa (155 aa) proteolipid of the V-type ATPase so that growth factor receptors are not processed properly and growth factor signal transduction pathways are stimulated. E6 and E7 proteins drive cell proliferation through their association with PDZ domain proteins and the retinoblastoma gene product.

Subjects: Medicine and Health.

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