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A member of the RP/EB family of proteins (adenomatous polyposis coli-binding protein EB1, microtubule-associated protein, RP/EB family member 1, MAPRE1, 268 aa) that was isolated in a two-hybrid screen of the APC protein (see adenomatous polyposis coli), to which it binds. During interphase it is bound to plus-ends of microtubules and during mitosis is associated with the centrosomes and spindle microtubules. Associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein.

Subjects: Medicine and Health.

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